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A rare patient case

69 years old

survived 30 years after lobotomy undertaking

1280 grams weighed brain

buffered formalin

Coronally sliced portions

Bilateral cystic lesions

Two cavities towards subcortex

The entry sites of the leukotome in prefrontal cortex

Assymetrical cysts were observed in the white matter

The frontal white matter around the cysts revealed marked loss of fibers and spongiosis specially near the cavities bilaterally

The thickness of the cortex was irregular in the whole frontal lobe

Shrinkage of neuronal cells, the number of neurons decreased

These finds were due to retrograde degeneration