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It is the lack of formation of the brain region (corpus callosum) produced by an alteration in embryonic development, it is a rare case of congenital disorder

The incidence is higher in genetic conditions such as trisomy 8 and trisomy 18

It may be accompanied by other malformations such as very small cerebral convolutions (microgyria), neuronal migration disorders or periventricular alterations.

It is not possible for the corpus callosum to be regenerated